Dead Cert: Measuring Cell Death

Is live problem better than dead cert?

Cholecystoduodenal fistula is a type of biliary enteric fistula that can occur as a result of chronic cholecystitis. The majority of cases are diagnosed and their subsequent management planned intraoperatively. Previous reports have focused on successful laparoscopic management. We report three cases of elective cholecystectomy that were diagnosed intraoperatively with a cholecystoduodenal fist...

Brain death, cardiac death, and the dead donor rule.

Hearts Not Dead after Circulatory Death

In recent weeks, two pioneering cardiac surgery teams, Dhital and colleagues in Australia (1) and Large and colleagues in the UK (2), reported on what could rapidly become the best and sole affordable solution to the relentlessly growing number of patients awaiting heart transplantation, i.e., transplantation of grafts obtained from donors after death following circulatory arrest, previously te...

Cert Research Annual Report

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.

Chromosomal instability (CIN) has been implicated in multidrug resistance and the silencing of the ceramide transporter, CERT, promotes sensitization to diverse cytotoxics. An improved understanding of mechanisms governing multidrug sensitization might provide insight into pathways contributing to the death of CIN cancer cells. Using an integrative functional genomics approach, we find that CER...